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One pot synthesis of isocyano-containing, densely functionalised <i>gem</i>-difluoroalkenes from <i>α</i>-trifluoromethyl alkenes, alkyl halides and TosMIC

Hongtai Huang, Junyu Chen, Yubo Jiang, Tiebo Xiao

2021Organic Chemistry Frontiers21 citationsDOI

Abstract

A base-promoted one-pot, three-component reaction of TosMIC with α -trifluoromethyl alkenes and alkyl halides has been deveolped for the synthesis of isocyano-containing, densely functionalised gem -difluoroalkenes.

Topics & Concepts

ChemistryHalideAlkylTrifluoromethylOrganic chemistryCombinatorial chemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsChemical Synthesis and Analysis
One pot synthesis of isocyano-containing, densely functionalised <i>gem</i>-difluoroalkenes from <i>α</i>-trifluoromethyl alkenes, alkyl halides and TosMIC | Litcius