Ferroptosis inhibition attenuates inflammatory response in mice with acute hypertriglyceridemic pancreatitis
Yi-Teng Meng, Yi Zhou, Peiyu Han, Hongbo Ren
Abstract
BACKGROUND: Ferroptosis is involved in developing inflammatory diseases; yet, its role in acute hypertriglyceridemic pancreatitis (HTGP) remains unclear. AIM: To explore whether ferroptosis is involved in the process of HTGP and elucidate its potential mechanisms. METHODS: were detected in the pancreas. Finally, immunohistochemistry was performed to assess the expression of ferroptosis-related proteins. RESULTS: < 0.05). Notably, the inhibition of ferroptosis and NOX2 attenuated the pathological damage and the release of TNF-α, IL-6, and IL-1β in the serum of the mice. CONCLUSION: Ferroptosis was found to have an important role in HTGP and may be considered a potential target for clinical treatment.