Identification of chalcone analogues as anti-inflammatory agents through the regulation of NF-κB and JNK activation
Die Zhang, Wenping Wang, Huiping Ou, Jinhua Ning, Yingxun Zhou, Ke Jin, Anguo Hou, Linyun Chen, Li Peng, Yunshu Ma, Wenbin Jin
Abstract
To develop new anti-inflammatory agents with improved pharmaceutical profiles, a series of chalcone analogues were designed and synthesized. The figure was drawn by Figdraw (http://www.figdraw.com).
Topics & Concepts
ChalconeChemistryAnti-inflammatoryIdentification (biology)NF-κBComputational biologyCombinatorial chemistryPharmacologyStereochemistryBiochemistryBiologyApoptosisBotanyPharmacological Effects of Natural CompoundsSynthesis and biological activityCytokine Signaling Pathways and Interactions