GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer
Eun Myoung Shin, Vinh Thang Huynh, Sultan Abda Neja, Chia Yi Liu, Anandhkumar Raju, Kelly Tan, Nguan Soon Tan, Jayantha Gunaratne, Xuezhi Bi, Lakshminarayan M. Iyer, L. Aravind, Vinay Tergaonkar
Abstract
exhibit growth and fertility defects reminiscent of phenotypes in ERα-null mice. In summary, this study identifies GREB1, a protein with an evolutionarily conserved domain related to DNA-modifying glycosyltransferases of bacteriophages and kinetoplastids, as the first inducible and the only other (apart from OGT) O-GlcNAc glycosyltransferase in mammalian cytoplasm and ERα as its first substrate.
Topics & Concepts
GlycosylationGlycosyltransferaseDomain (mathematical analysis)Protein stabilityBiologyComputational biologyProtein domainStability (learning theory)N-linked glycosylationCell biologyComputer scienceGeneticsGlycoproteinGlycanGeneMathematicsMathematical analysisMachine learningGlycosylation and Glycoproteins ResearchUbiquitin and proteasome pathwaysProtein Tyrosine Phosphatases