Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model
Yuhan Qu, Yue Shen, Li Teng, Yuehui Huang, Yuting Yang, Xi Jian, Shengli Fan, Ping Wu, Qiang Fu
Topics & Concepts
Nitric oxideTumor necrosis factor alphaChemistryProtein kinase BChondrocyteInflammationNitric oxide synthaseCaffeic acid phenethyl esterPharmacologyApoptosisPI3K/AKT/mTOR pathwayMatrix metalloproteinaseLY294002Cancer researchBiochemistryImmunologyMedicineIn vitroCaffeic acidAntioxidantOrganic chemistryOsteoarthritis Treatment and MechanismsNatural product bioactivities and synthesisInflammatory mediators and NSAID effects