Avoiding Regrettable Substitutions: Green Toxicology for Sustainable Chemistry
Alexandra Maertens, Emily Golden, Thomas Härtung
Abstract
Green chemistry seeks to design less hazardous chemicals, but many of the efforts to replace chemicals have resulted in so-called "Regrettable Substitutions", when a chemical with an unknown or unforeseen hazard is used to replace a chemical identified as problematic. Here, we discuss the literature on regrettable substitution and focus on an oft-mentioned case, Bisphenol A, which was replaced with Bisphenol S-and the lessons that can be learned from this history. In particular, we focus on how Green Toxicology can offer a way to make better substitutions.
Topics & Concepts
ChemistryNanotechnologyGreen chemistryBiochemical engineeringEnvironmental chemistryMaterials scienceEngineeringOrganic chemistryReaction mechanismCatalysisChemistry and Chemical EngineeringEffects and risks of endocrine disrupting chemicalsPharmaceutical and Antibiotic Environmental Impacts