Reduction of intracellular oxidative stress with a copper-incorporated layered double hydroxide
Adél Szerlauth, Tamara Madácsy, Gergely F. Samu, Péter Bíró, Miklós Erdélyi, Gábor Varga, Zhi Ping Xu, József Maléth, István Szilágyi
Abstract
Biocompatible Cu(II)-doped layered double hydroxide (CMA) nanoparticles were developed to combat reactive oxygen species. The 2-dimensional nanozymes showed both superoxide dismutase- and catalase-like activities in chemical assays, while proving as efficient antioxidants in the reduction of intracellular oxidative stress. The results indicate the great promise of CMA in antioxidant therapies.
Topics & Concepts
Oxidative stressCatalaseReactive oxygen speciesSuperoxide dismutaseHydroxideIntracellularChemistryAntioxidantCopperNanoparticleHydrogen peroxideRedoxCombinatorial chemistryNanotechnologyBiochemistryInorganic chemistryMaterials scienceOrganic chemistryAdvanced Nanomaterials in CatalysisAdvanced Photocatalysis TechniquesElectrochemical sensors and biosensors