ROS-responsive thermosensitive polypeptide hydrogels for localized drug delivery and improved tumor chemoimmunotherapy
Fujiang Li, Junfeng Ding, Zhenyu Li, Yan Rong, Chaoliang He, Xuesi Chen
Abstract
. Following intratumoral injection into mice bearing B16F10 melanoma, the Dox/R848/aPD-1 co-loaded hydrogel effectively inhibited tumor growth, prolonged animal survival time and promoted anti-tumor immune responses with low systemic toxicity. In the postoperative model, the Dox/R848/aPD-1 co-loaded hydrogel exhibited enhanced tumor recurrence prevention and long-term immune memory effects. Thus, the hydrogel-based local chemoimmunotherapy system demonstrates potential for effective anti-tumor treatment and suppression of tumor recurrence.
Topics & Concepts
ChemoimmunotherapySelf-healing hydrogelsChemistryDrug deliveryDrugCancer researchBiophysicsCell biologyPharmacologyImmunotherapyImmunologyMedicineImmune systemBiologyPolymer chemistryOrganic chemistryNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsCancer Research and Treatments