Design, synthesis and computational approach of vanillyl–imidazolidinyl–sulfamethoxazole derivatives as potent antimicrobial candidates tackling microbial resistance
Preetesh Kumar Panda, Kakarla Pakeeraiah, Suvadeep Mal, Monalisa Mahapatra, Ajit Kumar Bishoyi, Sudhir Kumar Paidesetty
Abstract
strain, which is better than that of ketoconazole. Following these findings, HOMO-LUMO analysis was carried out, and compound 4g showed the smallest energy gap of 3.15 eV. The antibacterial activity of imidazolones is more effective than oxazolones, whereas the action is reversed for fungal strains. To combat against resistant pathogens, multifaced treatments should be followed, and compounds such as 4d and 4g might play a significant role in this regard. The synthetic and biological outcome of the newer vanillyl-imidazolidinyl-sulfamethoxazole derivatives mark a footstep in the drug discovery pipeline in the bacterial resistance era.