Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/PAK1/MMP-2 signaling axis
Yu‐Yang Yi, Hao Chen, Shu‐Bao Zhang, Hao-Wei Xu, Xin-Yue Fang, Shan‐Jin Wang
Topics & Concepts
Extracellular matrixMatrix metalloproteinaseRAC1MMP2Cell biologyAngiogenesisKlothoDegeneration (medical)ExtracellularSignal transductionChemistryIntervertebral discPAK1Cancer researchBiologyAnatomyMedicinePathologyBiochemistryDownregulation and upregulationEndocrinologyKidneyGeneSpine and Intervertebral Disc PathologyParathyroid Disorders and TreatmentsTGF-β signaling in diseases