Engineered ketoreductase-catalyzed stereoselective reduction of ethyl 2′-ketopantothenate and its analogues: chemoenzymatic synthesis of <scp>d</scp>-pantothenic acid
Pan Hu, Xiaofan Wu, Yajiao Zhang, Minjie Liu, Yuan Tao, Zedu Huang, Fen‐Er Chen
Abstract
An asymmetric sustainable route to d -pantothenic acid was developed, centering on the reduction of ethyl 2′-ketopantothenate to ethyl ( R )-pantothenate, enabled by an E. coli strain co-expressing an engineered ketoreductase and glucose dehydrogenase.
Topics & Concepts
StereoselectivityChemistryCatalysisPantothenic acidEthyl esterCombinatorial chemistryStereochemistryBiochemistryOrganic chemistryVitaminNeurological diseases and metabolismEnzyme Catalysis and ImmobilizationChemical Synthesis and Analysis