Manufacturing Bacteriophages (Part 1 of 2): Cell Line Development, Upstream, and Downstream Considerations
Tayfun Tanir, Marvin Orellana, Aster Escalante, Carolina Moraes de Souza, Michael Koeris
Abstract
Within this first part of the two-part series on phage manufacturing, we will give an overview of the process leading to bacteriophages as a drug substance, before covering the formulation into a drug product in the second part. The principal goal is to provide the reader with a comprehensive framework of the challenges and opportunities that present themselves when developing manufacturing processes for bacteriophage-based products. We will examine cell line development for manufacture, upstream and downstream processes, while also covering the additional opportunities that engineered bacteriophages present.
Topics & Concepts
Downstream (manufacturing)Upstream (networking)Upstream and downstream (DNA)BacteriophageDownstream processingProcess (computing)Process developmentDrug developmentComputer scienceNew product developmentManufacturing engineeringEngineeringBusinessDrugBiologyOperations managementTelecommunicationsOperating systemGeneEscherichia coliPharmacologyBiochemistryMarketingBacteriophages and microbial interactionsMonoclonal and Polyclonal Antibodies ResearchBacterial Genetics and Biotechnology