Noise-induced neurophysiological alterations in the rat medial geniculate body and thalamocortical desynchronization by deep brain stimulation
Gusta van Zwieten, Mark Roberts, Frédéric L. V. W Schaper, Jasper V. Smit, Yasin Temel, Marcus L.F. Janssen
Abstract
Separate functional classes of MGB neurons might have distinct roles in tinnitus pathophysiology. After noise exposure, fast-responding neurons become less responsive or nonresponsive without change to their spontaneous firing, whereas sustained and suppressed neurons exhibit enhanced spontaneous activity without change to their stimulus-driven activity. Furthermore, results suggest desynchronization of thalamocortical β and γ oscillations as a mechanism of tinnitus suppression by MGB DBS.
Topics & Concepts
Medial geniculate bodyTinnitusNeurophysiologyNeuroscienceStimulationStimulus (psychology)Deep brain stimulationLocal field potentialInhibitory postsynaptic potentialPsychologyElectroencephalographyThalamusMedicineAudiologyInferior colliculusInternal medicineParkinson's diseaseNucleusDiseasePsychotherapistHearing, Cochlea, Tinnitus, GeneticsHearing Loss and RehabilitationNeural dynamics and brain function