Photodynamic activity of Sn(<scp>iv</scp>) tetrathien-2-ylchlorin against MCF-7 breast cancer cells
Balaji Babu, John Mack, Tebello Nyokong
Abstract
A new readily-synthesized Sn(iv) tetraarylchlorin with thien-2-yl substituents (SnC) has been prepared and fully characterized by various spectroscopic techniques and its photophysical and photochemical properties, such as the singlet oxygen quantum yield (ΦΔ), fluorescence quantum yield (ΦF), triplet lifetime (τT) and photostability, have been evaluated. SnC has an unusually high ΦΔ value of 0.89 in DMF. Studies on the photodynamic activity against MCF-7 breast cancer cells exhibited a very low IC50 value of 0.9 μM and high phototoxicity (dark versus light) indices of >27.8 after irradiation with a 660 nm Thorlabs LED (280 mW cm-2). The results demonstrate that Sn(iv) tetraarylchlorins of this type are suitable candidates for further in-depth PDT studies.