NELL1-Associated Membranous Glomerulopathy After Hematopoietic Stem Cell Transplantation
Satoru Kudose, Miroslav Sekulic, Collette J. Mehring, Dominick Santoriello, Ibrahim Batal, Michael B. Stokes, Vivette D. D’Agati, Glen S. Markowitz
Abstract
Membranous glomerulopathy (MGN) is among the most common glomerular diseases identified in adult patients with nephrotic syndrome. Traditionally, MGN is classified into primary and secondary forms depending on the clinical context (i.e., renal-limited vs. associated with a systemic disorder), with a presumed secondary etiology identified in approximately 30% of cases. Since the discovery of phospholipase A2 receptor (PLA2R) as a major target antigen in primary MGN,1 multiple additional antigenic targets have been discovered.
Topics & Concepts
MedicineNephrotic syndromeEtiologyMembranous nephropathyContext (archaeology)Hematopoietic stem cell transplantationGlomerulopathyImmunologyTransplantationHematopoietic stem cellPathologyGlomerulonephritisStem cellHaematopoiesisInternal medicineBiologyKidneyGeneticsPaleontologyRenal Diseases and GlomerulopathiesBiomedical Research and PathophysiologyGenetic and Kidney Cyst Diseases