Actin filament debranching regulates cell polarity during cell migration and asymmetric cell division
Chao Xie, Yuxiang Jiang, Zhiwen Zhu, Shanjin Huang, Wei Li, Guangshuo Ou
Abstract
one-cell-stage embryos, POD-1 and Arp2/3, moved together during cell polarity establishment, and inhibition of POD-1 blocked Arp2/3 motility and affected the polarized cortical flow, leading to symmetric segregation of cell fate determinants. Together, these results indicate that F-actin debranching organizes actin network and cell polarity in migrating neuroblasts and asymmetrically dividing embryos.
Topics & Concepts
Cell biologyCell polarityNeuroblastCell divisionPolarity (international relations)ActinAsymmetric cell divisionBiologyCell migrationActin remodelingCellActin cytoskeletonCytoskeletonGeneticsNeurogenesisGenetics, Aging, and Longevity in Model OrganismsCellular Mechanics and InteractionsSpaceflight effects on biology