Genome-Scale Metabolic Model of <i>Caldicellulosiruptor bescii</i> Reveals Optimal Metabolic Engineering Strategies for Bio-based Chemical Production
Ke Zhang, Weishu Zhao, Dmitry A. Rodionov, Gabriel M. Rubinstein, Diep Nguyen, Tania N. N. Tanwee, James R. Crosby, Ryan G. Bing, Robert M. Kelly, Michael W. W. Adams, Ying Zhang
Abstract
The extremely thermophilic cellulolytic bacterium, Caldicellulosiruptor bescii , degrades plant biomass at high temperatures without any pretreatments and can serve as a strategic platform for industrial applications. The metabolic engineering of C. bescii , however, faces potential bottlenecks in bio-based chemical productions.
Topics & Concepts
Metabolic engineeringBiochemical engineeringScale (ratio)Computational biologyProduction (economics)BiologyGeneGeneticsEngineeringEconomicsGeographyMacroeconomicsCartographyMicrobial Metabolic Engineering and BioproductionBiofuel production and bioconversionEnzyme Catalysis and Immobilization