Ginseng-derived exosome-like nanovesicles extracted by sucrose gradient ultracentrifugation to inhibit osteoclast differentiation
Kwansung Seo, Ji Hye Yoo, Jisu Kim, Sung Jun Min, Dong Nyoung Heo, Il Keun Kwon, Ho‐Jin Moon
Abstract
microcomputerized tomography, bone volume/total volume ratios, and bone mineral density and bone cavity measurements demonstrated the inhibitory effect of GDNs against osteoclast differentiation in lipopolysaccharide-induced bone resorption mouse models. The results of this work suggest that GDNs are anti-osteoporotic by inhibiting osteoclast differentiation and are, therefore, promising for use in the clinical prevention and treatment of bone loss diseases.
Topics & Concepts
UltracentrifugeExosomeChemistrySucroseMicrovesiclesOsteoclastGinsengSucrose gradientChromatographyBiochemistryCell biologyBiologyMembraneMedicinemicroRNAGenePathologyAlternative medicineIn vitroExtracellular vesicles in diseaseMicroRNA in disease regulationBone Metabolism and Diseases