Immunometabolic Targets in CD8<sup>+</sup> T Cells within the Tumor Microenvironment of Hepatocellular Carcinoma
Yanze Lin, Rexiati Ruze, Ruiqing Zhang, Talaiti Tuergan, Maolin Wang, Alimu Tulahong, Dalong Zhu, Zhongdian Yuan, Tiemin Jiang, Tuerganaili Aji, Yingmei Shao
Abstract
Background: CD8+ T cells are critical for the oncogenesis and progression of the hepatocellular carcinoma (HCC) tumor microenvironment, receiving antigen signals from antigen-presenting cells and directly contributing to antitumor responses. Summary: CD8+ T cells mediate immunogenic cell death, facilitate immune signal transmission, and play a significant role in various treatments, including surgery, transarterial chemoembolization, and immunotherapy. Extensive research on the role of CD8+ T cells within the HCC microenvironment has shown considerable progress. Immunometabolic targets on CD8+ T cells have demonstrated potential in combination with immunotherapies for HCC; however, they have not yet reached the clinical trial stage. Key Messages: This review provides a comprehensive overview of recent research on immune and immunometabolic targets of CD8+ T cells within the HCC microenvironment. By highlighting advances and potential mechanisms, this review aims to support the development of effective clinical strategies in this field.