A practical and sustainable protocol for direct amidation of unactivated esters under transition-metal-free and solvent-free conditions
Rui Zhang, Wei‐Zhong Yao, Liang Qian, Wei Sang, Ye Yuan, Minchen Du, Hua Cheng, Cheng Chen, Xin Qin
Abstract
An environmentally friendly and scalable protocol was developed for direct amidation of unactivated esters under transition-metal-free, solvent-free and chromatography-free conditions.
Topics & Concepts
ChemistryEnvironmentally friendlyTransition metalSolventOrganic chemistryProtocol (science)Combinatorial chemistryCatalysisAlternative medicineMedicineEcologyPathologyBiologyChemical Synthesis and AnalysisChemical Synthesis and ReactionsAsymmetric Hydrogenation and Catalysis