USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer
Xiaomeng Dai, Lisen Lu, Suke Deng, Jingshu Meng, Chao Wan, Jing Huang, Yajie Sun, Yan Hu, Bian Wu, Gang Wu, Jonathan F. Lovell, Honglin Jin, Kunyu Yang
Abstract
Taken together, these results provide evidence to suggest that therapeutic approaches targeting USP7, in combination with immunotherapy, should be considered for lung cancer treatment.
Topics & Concepts
ReprogrammingImmune systemLung cancerCancer researchCancerMacrophageMedicineImmunologyBiologyPathologyCellIn vitroInternal medicineBiochemistryGeneticsUbiquitin and proteasome pathwaysAutophagy in Disease and TherapyEpigenetics and DNA Methylation