The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis
Camila G. Quinonez, Jae Jin Lee, Ju‐Hyeon Lim, Mark Odell, Christopher P. Lawson, Amarachukwu Anyogu, Saki Raheem, Hyungjin Eoh
Abstract
Understanding the mechanisms underlying M. tuberculosis adaptive strategies to achieve drug tolerance is crucial for the identification of new targets and the development of new drugs. Here, we show that acetate medium triggers a drug-tolerant state in M. tuberculosis when challenged with antituberculosis (anti-TB) drugs.
Topics & Concepts
Mycobacterium tuberculosisTuberculosisMetabolomicsIsoniazidGlycerolBiochemistryFatty acidMicrobiologyMetabolismChemistryBiologyMedicinePathologyChromatographyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisBiochemical and Molecular Research