Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats
Hanxiang Sun, Xiujuan Su, Yang Liu, Guohua Li, Qiaoling Du
Abstract
(R.I) is the key bacteria in ICP. Transplantation of R.I improved phenotypes associated with ICP through the bile acid/farnesoid X receptor-fibroblast growth factor 15 (FXR-FGF15) signaling pathway. We used the FXR antagonist Z-Guggulsterone (Z-Gu) to verify the key role of FXR in ICP and found that Z-Gu reversed the benefits of R.I on ICP rats. Our research highlights the important role of intestinal flora in the pathogenesis of ICP and provides a novel approach for its treatment.
Topics & Concepts
Farnesoid X receptorCholestasis of pregnancyBile acidCholestasisUrsodeoxycholic acidBiologyFGF19Internal medicinePregnancyEndocrinologyFibroblast growth factorMedicineBiochemistryReceptorNuclear receptorFetusTranscription factorGeneGeneticsPancreatitis Pathology and TreatmentPediatric Hepatobiliary Diseases and TreatmentsPancreatic and Hepatic Oncology Research