QTc Prolongation Secondary to Zolpidem Use

Laura Suarez, Bhanu Prakash Kolla, Daniel K. Hall‐Flavin, Meghna P. Mansukhani

2020The Primary Care Companion For CNS Disorders11 citationsDOI

Abstract

Article AbstractBecause this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.Drug-induced long QT syndrome (LQTS) can be life-threatening and increase the risk of ventricular tachycardia, specifically torsades de pointes (TdP). There are several risk factors for LQTS including female sex, personal history of drug-induced LQTS, family history of congenital LQTS, hypokalemia, structural heart disease, bradycardia, atrioventricular block, concomitant use of QT-prolonging agents, and use of certain medications.Zolpidem is a nonbenzodiazepine benzodiazepine receptor agonist (nBBRA) used to treat insomnia. There is 1 previous case report4 of LQTS resulting from concurrent zolpidem and amiodarone use.

Topics & Concepts

Torsades de pointesZolpidemMedicineLong QT syndromeBradycardiaQT intervalhERGAnesthesiaInternal medicineCardiologyAmiodaronePharmacologyAtrial fibrillationInsomniaHeart rateBlood pressurePotassium channelCardiac electrophysiology and arrhythmiasECG Monitoring and Analysis