Benzenesulfonohydrazide-tethered non-fused and fused heterocycles as potential anti-mycobacterial agents targeting enoyl acyl carrier protein reductase (InhA) with antibiofilm activity
Tarfah Al‐Warhi, Ahmed Sabt, Małgorzata Korycka‐Machała, Asmaa F. Kassem, Moataz A. Shaldam, Hoda Atef Abdelsattar Ibrahim, Malwina Kawka, Bożena Dziadek, Magdalena Kuzioła, Wagdy M. Eldehna, Jarosław Dziadek
Abstract
value of 0.91 μM. The findings showed that the sulfonamide and methyl ester's carbonyl functionalities were engaged in hydrogen bonding with the essential Ile194 and Tyr158 residues, respectively.
Topics & Concepts
INHAChemistryReductaseCombinatorial chemistryBiochemistryStereochemistryEnzymeIsoniazidMedicineTuberculosisPathologyChemical Synthesis and AnalysisSynthesis and biological activitySynthesis of β-Lactam Compounds