Discovery of Desmuramylpeptide NOD2 Agonists with Single-Digit Nanomolar Potency
Samo Guzelj, Špela Bizjak, Žiga Jakopin
Abstract
acted synergistically with lipopolysaccharide and interferon-γ to induce the production of cytokines in human peripheral blood mononuclear cells and enhance their nonspecific cytotoxic activity against K562 cancer cells. These findings provide initial insight into its immunostimulatory potential, especially when used in combination with other immunopotentiators.
Topics & Concepts
PotencyComputer scienceNumerical digitPharmacologyMedicineComputational biologyChemistryArithmeticBiologyMathematicsBiochemistryIn vitroRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesMicroRNA in disease regulation