The Expression of Perilipin Family Proteins can be used as Diagnostic Markers of Liposarcoma and to Differentiate Subtypes
Qiaochu Zhang, Pengpeng Zhang, Bingcheng Li, Hongwei Dang, Jinfang Jiang, Lian Meng, Haijun Zhang, Yangyang Zhang, Xiaomeng Wang, Qianru Li, Yang Wang, Chunxia Liu, Feng Li
Abstract
Objective: Liposarcoma is a mesenchymal malignant tumor characterized by adipocyte differentiation which is divided into four subtypes with different prognosis. Accurate histopathological diagnosis is essential for precise treatment. Perilipins, including PLIN1, PLIN2, PLIN3, PLIN4, PLIN5, is a family of lipid droplet-associated proteins that participate in lipid metabolism regulation. The role that perilipins play in sarcomas is not clear. This study aims to assess perilipins expression in subtypes of liposarcoma and various non-lipomatous sarcomas.
Topics & Concepts
LiposarcomaPerilipinPathologySarcomaMyxoid liposarcomaDermatofibrosarcoma protuberansImmunohistochemistryMedicineCancer researchBiologyAdipose tissueAdipocyteInternal medicineLipid metabolism and biosynthesisResearch in Cotton CultivationPlant biochemistry and biosynthesis