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Intercellular bridges coordinate the transition from pluripotency to meiosis in mouse fetal oocytes

Bikem Soygur, Rebecca G. Jaszczak, Adam Fries, Daniel H. Nguyen, Safia Malki, Guang Hu, Necdet Demır, Ripla Arora, Diana J. Laird

2021Science Advances55 citationsDOIOpen Access PDF

Abstract

Together, these results lead to a model that ICBs coordinate and buffer the transition from pluripotency to meiosis through dilution of regulatory factors.

Topics & Concepts

Cell biologyMeiosisTransition (genetics)IntracellularOocyteBiologyFetusEmbryoGeneticsPregnancyGeneEpigenetics and DNA MethylationPluripotent Stem Cells ResearchPrenatal Screening and Diagnostics