Human Fecal Mucin Glycosylation as a New Biomarker in Inflammatory Bowel Diseases
Catherine Robbe‐Masselot, Camille Cordier, Benjamin Marsac, Maria Nachury, Renaud Léonard, Boualem Sendid
Abstract
Lay Summary For the first time, fecal mucins of Crohn’s disease patients were analyzed by mass spectrometry. Compared with control subjects, Crohn’s disease patients showed a significant decrease in sialylated glycans that we propose as new noninvasive tool for screening of intestinal diseases.
Topics & Concepts
MucinInflammatory bowel diseaseBiomarkerFecesCrohn's diseaseGlycosylationMedicineGlycanGastroenterologyUlcerative colitisInflammatory Bowel DiseasesBiomarker discoveryDiseaseInternal medicineImmunologyPathologyBiologyProteomicsMicrobiologyGlycoproteinBiochemistryGeneGlycosylation and Glycoproteins ResearchHelicobacter pylori-related gastroenterology studiesGalectins and Cancer Biology