Pd/Cu-Catalyzed Domino Cyclization/Deborylation of Alkene-Tethered Carbamoyl Chloride and 1,1-Diborylmethane
Chenhuan Zhang, Xianqing Wu, Chenchen Wang, Chengxi Zhang, Jingping Qü, Yifeng Chen
Abstract
Reported herein is a palladium/copper cooperative-catalyzed dicarbofunctionalization of alkene-tethered carbamoyl chlorides with 1,1-diborylmethane. This cyclization/deborylation cascade strategy allows for the expedient formation of the versatile borylated 3,3-disubstituted oxindole skeleton, allowing for further functionalization via the derivatization of the carbon-boron bond.
Topics & Concepts
ChemistryOxindoleAlkeneCatalysisDominoCascade reactionCombinatorial chemistrySurface modificationDerivatizationTandemPalladiumMedicinal chemistryOrganic chemistryPhysical chemistryMaterials scienceComposite materialHigh-performance liquid chromatographyCatalytic Cross-Coupling ReactionsOrganoboron and organosilicon chemistryCatalytic C–H Functionalization Methods