Molecular signatures underlying heterogenous hypertrophy responsiveness to resistance training in older men and women: a within-subject design
Manoel E. Lixandrão, Marcas M. Bamman, Kaleen M. Lavin, Igor Longobardi, Guilherme Defante Telles, Felipe C. Vechin, Felipe Damas, Devin Drummer, Jeremy S. McAdam, Luiz Augusto Riani Costa, Cleiton Augusto Libardi, Bruno Gualano, Hamilton Roschel
Abstract
We showed that higher RT volume increased total protein expression of Frizzled-1. High responder's robust hypertrophy was followed by upregulation of pathways linked with protein turnover metabolism and RT-related metabolic response. Hypertrophy in medium responders, on the other hand, was marked by downregulation of pathways associated with proteasome and spliceosome, and upregulation of lipoproteins metabolisms and genes was associated with membrane trafficking and intracellular protein transport. These findings reveal differential molecular signatures across the spectrum of RT responsiveness among older individuals in response to different RT volume manipulations.