Dual inhibition of TGFβ signaling and CSF1/CSF1R reprograms tumor-infiltrating macrophages and improves response to chemotherapy via suppressing PD-L1
Tsung-Wei Chen, Wei-Ze Hung, Shu‐Fen Chiang, William Tzu‐Liang Chen, Tao‐Wei Ke, Ji‐An Liang, Chih-Yang Huang, Pei-Chen Yang, Kevin Chih‐Yang Huang, K. S. Clifford Chao
Topics & Concepts
Tumor microenvironmentCancer researchCytotoxic T cellDownregulation and upregulationImmune systemCD8ChemotherapyColorectal cancerTransforming growth factorImmunotherapyBiologyCancerImmunologyMedicineInternal medicineCell biologyGeneBiochemistryIn vitroCancer Immunotherapy and BiomarkersImmune cells in cancerImmune Cell Function and Interaction