Biosynthesis of the redox cofactor mycofactocin is controlled by the transcriptional regulator MftR and induced by long-chain acyl-CoA species
Aigera Mendauletova, John Latham
Abstract
155 when oleic acid is supplemented to the media. These results suggest that MftR controls expression of the mft BGC and that MFT production is induced by long-chain acyl-CoAs. Since MFT-dependent dehydrogenases are known to colocalize with acyl carrier protein/CoA-modifying enzymes, these results suggest that MFT might be critical for fatty acid metabolism or cell wall reorganization.
Topics & Concepts
RegulatorCofactorRedoxBiosynthesisChemistryBiochemistryTranscriptional regulationCoenzyme AOxidation reductionChain (unit)Cell biologyBiologyEnzymeTranscription factorGeneReductaseOrganic chemistryAstronomyPhysicsMicrobial metabolism and enzyme functionMicrobial Metabolic Engineering and BioproductionMetal-Catalyzed Oxygenation Mechanisms