Asiatic acid as a leading structure for derivatives combining sub-nanomolar cytotoxicity, high selectivity, and the ability to overcome drug resistance in human preclinical tumor models
Oliver Kraft, Anne-Kathrin Hartmann, Sarah Brandt, Sophie Hoenke, Niels V. Heise, René Csük, Thomas Mueller
Topics & Concepts
CytotoxicityRhodamine 123ChemistryHeLaCytotoxic T cellApoptosisCell cultureCancer researchBiochemistryPharmacologyMultiple drug resistanceIn vitroBiologyGeneticsAntibioticsMedicinal Plants and NeuroprotectionNatural product bioactivities and synthesisEssential Oils and Antimicrobial Activity