Compound-composed Chinese medicine of Huachansu triggers apoptosis of gastric cancer cells through increase of reactive oxygen species levels and suppression of proteasome activities
Yiqing Deng, Min Gao, D Lu, Qiuping Liu, Runjing Zhang, Ji Ye, Jing Zhao, Zhihui Feng, Qizhang Li, Hong Zhang, Hong Zhang
Topics & Concepts
BufalinApoptosisReactive oxygen speciesProtein kinase BCancer cellCancerPharmacologyViability assayCell cyclePI3K/AKT/mTOR pathwayCell cycle checkpointMAPK/ERK pathwayChemistryProteasomeSignal transductionCancer researchBiologyMedicineBiochemistryInternal medicineFlavonoids in Medical ResearchCell death mechanisms and regulationNatural product bioactivities and synthesis