WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism
Qiuhong Xiong, Huimin Sun, Wenxiu Xing, Xin Li, Guangxin Chen, Zhonghua Zhao, Changxin Wu, Ping Li, Ping Li
Topics & Concepts
Unfolded protein responseAutophagyFerritinCell biologyp38 mitogen-activated protein kinasesMutantChemistryHomeostasisEndoplasmic reticulumChaperone (clinical)ProteostasisSignal transductionMAPK/ERK pathwayBiologyBiochemistryGeneApoptosisPathologyMedicineEndoplasmic Reticulum Stress and DiseaseNeurological diseases and metabolismAutophagy in Disease and Therapy