The positive effects and underlying mechanisms of <i>Undaria pinnatifida</i> polysaccharides on type 2 diabetes mellitus in rats
Zhao‐Rong Li, Rui‐Bo Jia, Donghui Luo, Lianzhu Lin, Qianwen Zheng, Mouming Zhao
Abstract
. Furthermore, RT-qPCR analysis results clarified that UPP administration distinctly activated the IRS/PI3K/AKT signaling pathway, restrained PEPCK, G-6-Pase and Egr-1 genes, and affected the relative expression of HMGCR and LDLR genes. This study demonstrates that UPP could be applied as an adjuvant agent for the management of T2DM.
Topics & Concepts
PolysaccharideDiabetes mellitusType 2 Diabetes MellitusType 2 diabetesChemistryBiologyTraditional medicineFood scienceBiochemistryEndocrinologyMedicineMicrobial Metabolites in Food BiotechnologyPolysaccharides and Plant Cell WallsSeaweed-derived Bioactive Compounds