Indazolone‐Assisted Sequential <i>ortho</i>‐Alkenylation‐Oxidative Aza‐Michael Addition of 1‐Arylindazolone Using Acrylates Under Ru(II) Catalysis
Chikkagundagal K. Mahesha, Sanjay K. Mandal, Rajeev Sakhuja
Abstract
Abstract A one‐pot annulation of 1‐arylindazolones and acrylates is achieved through Ru(II)‐catalyzed sequential ortho ‐alkenylation followed by oxidative intramolecular aza‐Michael addition reaction to deliver substituted indazolo[1,2‐ a ]indazolylidenes in good‐to‐excellent yields. The strategy showcased high functional group tolerance and the directing group ability of indazolone moiety was established for Csp 2 ‐H bond activation.
Topics & Concepts
ChemistryIntramolecular forceMoietyCatalysisOxidative phosphorylationMichael reactionFunctional groupAnnulationCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryBiochemistryPolymerCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthesis of Indole Derivatives