Bbvac: A Live Vaccine Candidate That Provides Long-Lasting Anamnestic and Th17-Mediated Immunity against the Three Classical <i>Bordetella</i> spp.
Mónica Cartelle Gestal, Laura K. Howard, Kalyan K. Dewan, Eric T. Harvill
Abstract
Infectious diseases are a major cause of morbidity and mortality in the United States, accounting for over 40 million hospitalizations since 1998. Therefore, novel vaccine strategies are imperative, which can be improved with a better understanding of the mechanisms that bacteria utilize to suppress host immunity, a key mechanism for establishing colonization. Bordetella spp., the causative agents of whooping cough, suppress host immunity, which allows for persistent colonization.
Topics & Concepts
Bordetella pertussisColonizationImmunityWhooping coughBordetellaHost (biology)ImmunologyBiologyMedicineMicrobiologyVaccinationImmune systemBacteriaEcologyGeneticsBacterial Infections and VaccinesInfluenza Virus Research StudiesPneumonia and Respiratory Infections