Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart
Rui Shang, Nathaniel Lal, Chae Syng Lee, Yajie Zhai, Karanjit Puri, Oscar Seira, Robert Boushel, Ibrahim Sultan, Markus Räsänen, Kari Alitalo, Bahira Hussein, Brian Rodrigues
Abstract
In hearts overexpressing vascular endothelial growth factor B (VEGFB), besides its known angiogenic response, multiple regulatory mechanisms lowered coronary LPL. This was accompanied by limited cardiac lipid metabolite accumulation with an augmentation of cardiac insulin action. Our data for the first time links VEGFB to coronary LPL in regulation of cardiac metabolism. VEGFB may be cardioprotective in metabolic disorders like diabetes.
Topics & Concepts
Internal medicineBiologyEndocrinologyLipoprotein lipaseLipotoxicityInsulinAdipose tissueInsulin resistanceMedicineLipid metabolism and disordersCardiovascular Function and Risk FactorsDiabetes, Cardiovascular Risks, and Lipoproteins