Restoration of RNA helicase DDX5 suppresses hepatitis B virus (HBV) biosynthesis and Wnt signaling in HBV-related hepatocellular carcinoma
Saravana Kumar Kailasam Mani, Bingyu Yan, Zhibin Cui, Jiazeng Sun, Sagar M. Utturkar, Adrien Foca, Nadim Farés, David Durantel, Nadia A. Lanman, Philippe Merle, Majid Kazemian, Ourania Andrisani
Abstract
DDX5 is a negative regulator of Wnt signaling and hepatocyte reprogramming in HCCs. Restoration of DDX5 levels by miR17~92 / miR106b~25 antagomirs in HBV-infected patients can be explored as both antitumor and antiviral strategy.
Topics & Concepts
Hepatocellular carcinomaWnt signaling pathwayRNA Helicase AVirologyHepatitis B virusRNAHelicaseBiologyVirusCancer researchMedicineSignal transductionCell biologyGeneGeneticsRNA modifications and cancerHepatitis B Virus StudiesCancer-related gene regulation