Precise delivery of celastrol by PEGylated aptamer dendrimer nanoconjugates for enormous therapeutic effect via superior intratumor penetration over antibody counterparts
Boning Niu, Yuehuang Wu, Min Zhou, Ruimiao Lin, Pengjin Ge, Pengjin Ge, Hu Zhou, Xiao-kun Zhang, Jingjing Xie, Jingjing Xie
Topics & Concepts
AptamerCelastrolDendrimerPEGylationAntibodyChemistryCancer researchDrug deliveryImmunotherapyPharmacologyNanotechnologyImmune systemMedicineMaterials scienceImmunologyMolecular biologyPolyethylene glycolBiochemistryBiologyApoptosisRNA Interference and Gene DeliveryMultiple Myeloma Research and TreatmentsImmunotherapy and Immune Responses