Cancer Protective Role of Selected Dietary Polyphenols via Modulating Keap1/Nrf2/ARE and Interconnected Signaling Pathways
Md. Arman Islam, Maisha Maliha Medha, Akhlak Un Nahar, Md. Abdullah Al Fahad, Md Afjalus Siraj, Véronique Seidel
Abstract
studies to confirm the cancer protective role of methyleugenol, carnosol, and catechin, as well as further clinical trials to unambiguously establish whether the consumption of dietary polyphenols impacts on the incidence and progression of cancers in humans.
Topics & Concepts
KEAP1PI3K/AKT/mTOR pathwaySignal transductionOxidative stressCancerProtein kinase BMedicineAMPKCancer researchRegulatorMAPK/ERK pathwayAntioxidantPharmacologyPhosphorylationBiologyBiochemistryInternal medicineProtein kinase ATranscription factorGeneGenomics, phytochemicals, and oxidative stressPhytochemicals and Antioxidant ActivitiesGlutathione Transferases and Polymorphisms