A Novel SXT/R391 Integrative and Conjugative Element Carries Two Copies of the <i>bla</i> <sub>NDM-1</sub> Gene in Proteus mirabilis
Jintao He, Long Sun, Linghong Zhang, Sebastián Leptihn, Yunsong Yu, Xiaoting Hua
Abstract
The occurrence of carbapenemase-producing Proteus mirabilis , especially those strains producing NDM-1 and its variants, is a major public health concern worldwide. The integrative conjugative element (ICE) plays an important role in horizontal acquisition of resistance genes.
Topics & Concepts
Proteus mirabilisGeneProteusBiologyGeneticsElement (criminal law)MicrobiologyComputational biologyPolitical scienceEscherichia coliLawAntibiotic Resistance in BacteriaBacteriophages and microbial interactionsBacterial biofilms and quorum sensing