Cell-autonomous control of intracellular temperature by unsaturation of phospholipid acyl chains
Akira Murakami, Kohjiro Nagao, Reiko Sakaguchi, Keisuke Kida, Yuji Hara, Yasuo Mori, Kohki Okabe, Yoshie Harada, Masato Umeda
Abstract
-ATPase-dependent mitochondrial respiration is potentiated by cold exposure through the remodeling of mitochondrial cristae structures via DESAT1-dependent unsaturation of mitochondrial phospholipid acyl chains. Based on these findings, we propose a cell-autonomous mechanism for intracellular temperature control during environmental temperature changes.
Topics & Concepts
IntracellularDegree of unsaturationPhospholipidCell biologyMitochondrionBiochemistryBiophysicsBiologyRespirationChemistryMembraneBotanyOrganic chemistryATP Synthase and ATPases ResearchMitochondrial Function and PathologyAdipose Tissue and Metabolism