Myeloid Metabolism as a New Target for Rejuvenation?-Comments on Restoring Metabolism of Myeloid Cells Reverses Cognitive Decline in Ageing. Nature. 2021 Feb;590(7844)122-128
Marlen Knobloch, Rosa Chiara Paolicelli
Abstract
Research led by Katrin Andreasson suggests that fixing age-induced metabolic defects in myeloid cells would suffice to reverse cognitive impairment and to restore synaptic plasticity to the level of young subjects, at least in mice. This opens up the possibility to develop rejuvenating strategies by targeting immune dysfunction.
Topics & Concepts
Myeloid cellsCognitive declineAgeingMyeloidNeuroscienceCognitionImmune DysfunctionImmune systemBiologyRejuvenationMedicinePsychologyGerontologyImmunologyInternal medicineDementiaDiseaseNeuroinflammation and Neurodegeneration MechanismsImmune cells in cancerTryptophan and brain disorders