Hereditary persistence of fetal hemoglobin
DharmeshChandra Sharma, Sachin Singhal, Poonam Woike, Sunita Rai, Mahesh Yadav, Rajesh Gaur
Abstract
Hereditary persistence of fetal hemoglobin (HPFH) is a benign condition in which significant fetal hemoglobin production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced. The percentage of incorrect expression might be as low as 10%-15% or as high as 100% of the total hemoglobin, usually higher in homozygotes than in heterozygotes. The present case is a typical example of homozygous HPFH.
Topics & Concepts
MedicineFetal hemoglobinHemoglobinFetusHeterozygote advantagePersistence (discontinuity)AndrologyPhysiologyInternal medicinePregnancyGeneticsGeneBiologyGenotypeEngineeringGeotechnical engineeringHemoglobinopathies and Related DisordersIron Metabolism and DisordersBlood groups and transfusion