Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease
Xiansi Zeng, Wen-Shuo Geng, Yu Zhang, Jiayi Yin, Guangtao Xu, Meng Yu, Li Li, Jing Jia
Topics & Concepts
Hsp90CDC37Substantia nigraHeat shock proteinEndoplasmic reticulumChaperone (clinical)Alpha-synucleinUnfolded protein responseMPTPChemistryCell biologyParkinson's diseaseBiologyBiochemistryInternal medicineMedicineDiseasePathologyGeneEndoplasmic Reticulum Stress and DiseaseHeat shock proteins researchRedox biology and oxidative stress