Electrochemical Carboarylation of Activated Alkenes with <scp>CO<sub>2</sub></scp> and Electron‐deficient Aryl Bromides
Zhaoliang Yang, Chunlei Liu, Cheng Zhong, Jianye Zhang, Shengzhang Liu, Mingming Yu, Yangyang Li, Hong Yi, Aiwen Lei
Abstract
Comprehensive Summary The simultaneous construction of two vicinal C—C bonds in a molecule remains a significant challenge. In this work, we disclose an electroreductive carboarylation of activated alkenes under mild, transition metal‐free conditions. Utilizing readily available starting materials (electron‐deficient aryl bromides, activated alkenes, and CO 2 ), this method demonstrates broad substrate scope and good functional group tolerance. Notably, this strategy enables the addition of two distinct electrophiles across an alkene in a highly chemo‐ and regioselective manner.
Topics & Concepts
ChemistryArylElectrochemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryElectrodeAlkylPhysical chemistryCO2 Reduction Techniques and CatalystsCarbon dioxide utilization in catalysisCatalytic C–H Functionalization Methods