Modulation of blood pressure by dietary potassium and sodium: sex differences and modeling analysis
Melissa M. Stadt, Anita T. Layton
Abstract
Excessive dietary Na + raises blood pressure, whereas a high K + diet has the opposite effect. The underlying mechanisms are moderated by sex and involve multiple organs and tissues. How do high K + -induced alternations in kidney function lower blood pressure, and how do those mechanisms differ between men and women? To answer these questions, we conducted computer simulations to simulate whole-body fluid and electrolyte homeostasis, and the effects of Na + and K + intake on blood pressure.
Topics & Concepts
EndocrinologyInternal medicineKaliuresisBlood pressureNatriuresisSympathetic nervous systemRenin–angiotensin systemAldosteroneKidneyHomeostasisReabsorptionAutonomic nervous systemRenal functionRenal blood flowChemistryMedicineHeart rateSodium Intake and Health